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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T82758 | CDK9-Cyclin T1 PPI-IN-1 | CDK | Cell Cycle/Checkpoint |
CDK9-Cyclin T1 PPI-IN-1 (Compound B19) 是CDK9-Cyclin T1蛋白-蛋白相互作用的选择性抑制剂。该化合物能够有效抑制TNBC MDA-MB-231细胞系的细胞增殖(IC50: 0.044 μM),诱导细胞凋亡,同时降低CDK9的转录活性并减少RNA Pol II CTD ser2的磷酸化,有效地抑制了4T1移植瘤模型小鼠中肿瘤的生长。 | |||
T79274 |
PRMT5-IN-31
|
Histone Methyltransferase | Chromatin/Epigenetic |
PRMT5-IN-31(Compound 3m)作为一种高选择性PRMT5抑制剂,其IC50为0.31 μM。它能够通过占据PRMT5的底物位点以及与氨基酸残基形成必要相互作用来上调hnRNP E1蛋白水平。此外,PRMT5-IN-31能有效抑制A549细胞增殖,其机制涉及诱导apoptosis和阻碍细胞迁移。该化合物在人肝微粒体中表现出较高的代谢稳定性,半衰期为132.4分钟。 | |||
T79275 |
Antiproliferative agent-25
|
Histone Methyltransferase | Chromatin/Epigenetic |
Antiproliferative agent-25 (Compound 3s4)作为一种选择性PRMT5抑制剂(IC50: 0.11 μM),能够上调hnRNP E1蛋白水平,并通过与SAM及PRMT5的E444残基形成氢键相互作用。该化合物通过促进apoptosis和抑制细胞迁移,有效抑制A549细胞的增殖。此外,Antiproliferative agent-25在人和大鼠肝微粒体中的高清除率表明,其T1/2分别为21.8和4.7分钟。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00850 |
ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His)
Protein T1,suppression of tumorigenicity 2... |
Mouse | HEK293 Cells |
ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 55-70 KDa and the accession number is P14719-2. | |||
TMPJ-00849 |
ST2/IL-1 RL1 Protein, Mouse, Recombinant (V192A, hFc)
Protein ST2,IL-1 R4,IL-33R,ST2V,suppression of tumo... |
Mouse | HEK293 Cells |
ST2/IL-1 RL1 Protein, Mouse, Recombinant (V192A, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 90-110 KDa and the accession number is P14719-2. |